Does CBG Work for Pain? What The Research Says Skip to content
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Does CBG work for Pain?


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CBG’s potential benefits are attracting many CBD users, as its effects are different from those of the more well-known cannabinoid CBD. CBG interacts with the body's endocannabinoid system, which regulates various physiological processes, including pain sensation. 

Some early research suggests that CBG may have neuroprotective and anti-inflammatory effects that may benefit people with arthritis, inflammatory bowel disease, nerve pain, and chronic muscle pain. However, it hasn’t been FDA-approved to treat any health condition. Much of the research surrounding CBG is still in its very early stages, so there’s still much to discover about its potential. 

With that said, many people are taking their wellness into their own hands and experimenting with CBG products to support different kinds of pain. 

Does CBG Help for Pain?

Research suggests that CBG may decrease many types of pain, including pain from IBS, IBD, stomach pain, colitis, inflammation, and some nerve pain. Note that all studies on CBG are pre-clinical , and further clinical trials with humans are needed. Further, the FDA has not approved CBG as a cure or medication for any condition.

Still, anecdotal reports from our customers and others show positive results. We recommend doing your own research and making an informed decision. We look forward to future developments around this promising cannabinoid.

Also, it’s important to remember that CBG is a natural, hemp-derived compound that acts more like a dietary supplement rather than a medication, so its effects may be much more subtle and can vary on the individual. 

As we mentioned, CBG interacts with the endocannabinoid system, specifically binds to cannabinoid receptors, such as the CB1 and CB2 receptors. Anadamine, a naturally occurring cannabinoid in the body, binds primarily to CB1 receptors in the brain, influencing mood and pain perception.

CBG has been observed to influence anandamide by inhibiting the enzyme FAAH, which is responsible for breaking down anandamide [1]. By helping to maintain higher levels of anandamide in the body, cannabinoids like CBG may help with pain perception.  

A recent study demonstrates that a high daily CBG dosage reduces the severity of inflammatory bowel disease in murine models [2]. Studies like this lead compounds like CBG in the right direction for more research. Pathways for inflammation in mice and humans are similar, but some major differences must be explored further to understand its real potential in human health conditions. 

Beautiful young woman with worried frustrated look holding hands around her neck feeling pain

Should I Take CBD or CBG for Pain?

The decision to use CBD or CBG for discomfort depends on personal preferences and how your body responds to each cannabinoid. Both CBD and CBG interaction with the endocannabinoid system can vary from person to person.

Many people take CBD or CBG for mild discomfort. Pain is a signal that something’s wrong. If you’re experiencing chronic or acute pain, you must seek medical attention to rule out anything serious. 

Another thing to consider is that CBD is more widely available than CBG products and also has more research on its effects on discomfort. You can also find CBD in more types of cannabinoid products, such as oils, creams, edibles, and capsules. This wide variety may provide more options to meet a wider net of needs.

Anecdotal evidence and some research have shown that CBG and CBD both have the potential to support stress and healthy inflammation, which can benefit certain conditions, such as chronic and neuropathic pain. While neither of them treats these conditions, many people have found CBD and CBG helpful in managing discomfort. 

However, there may be more benefits to a CBD + CBG combined product

CBD + CBG for Pain Products

There are several reasons why you may want to use a combined product:

  • CBD and CBG may work better together than alone; a phenomenon known as the "entourage effect” occurs when combined. This means they can enhance each other's properties for more desirable effects.
  • CBG is often noted for its mood support, while CBD is known for its calming effects. Combining the two cannabinoids may lead to appealing mood effects. 
  • Both CBD and CBG support healthy inflammation. Since inflammation often contributes to pain, using both cannabinoids together may more effectively support inflammation.

Best CBG for Pain

Pain management is not a “one size fits all” situation. However, one CBG product may be more effective for a wider variety of uses or may more closely fit your plan for regulating pain. 

The Best CBG Products for Pain:

  • Best CBG Product for Pain: Neurogan CBG Gummies
  • Best CBG Product for Topical Pain: CBDfx CBG + CBD Cream
  • Best CBG Capsules for Pain: NuLeaf CBG Capsules
  • Neurogan CBG Gummies

    A bottle of Neurogan CBG Gummies

    Our criteria for what makes a CBG product great apply to our own CBG products. Our CBG Focus Gummies have a potent dose of 45 mg of CBG per gummy. 

    Many people associate gummies and edibles with evening, post-work routines, but with these gummies, we recommend taking them in the morning or daytime for best results. Plus, with a full-spectrum formula, your focus for the day will feel the benefits of a combination of cannabinoids.

    CBDfx CBG + CBD Cream

    A bottle of CBDfx CBG + CBD Cream

    Not everyone is into consuming supplements to support aches and pains. Infused creams are perfect for those seeking topical options as they don’t have systemic side effects that could sometimes upset people's stomachs or cause feelings of drowsiness. 

    CBDfx’s CBG + CBD Lotion is a CBG product worth trying out. Its heating formula and balanced CBG and CBD ratio make it a great topical option to keep in your gym bag or medicine cabinet. You can also choose the product's strength to match your needs, so choose between a 1:1 ratio of 1000 mg of CBD/ CBG or 3000 mg of CBG/CBD. 

    While CBD topicals generally don’t get you high, it depends on the potency and individual. However, the typical experience is non-psychoactive.

    NuLeaf CBD Capsules

    A bottle of NuLeaf CBD Capsules

    NuLeaf Natural’s CBG Capsules include a full spectrum of cannabinoids, such as CBG, CBD, CBC, and CBN. With CBG as the star of the show in these capsules, each capsule contains 15 mg of CBG. 

    This means that each serving (2 capsules) contains 30 mg of CBG. This moderate dose can be taken daily for consistent benefits.  You can also choose between a 30 or 60 day supply for your convenience and preference. 

    The Takeaway: Does CBG for Pain

    Pain relief isn’t a straightforward thing. Pain is a highly individualized experience, and what works for one person may not work for another. It’s important to know that CBG products are not meant to replace treatment or advice from your doctor. Managing pain, especially chronic or nerve pain, requires guidance from a healthcare professional. Always advise your doctor before self-treating any condition. 

    References:

    1. Navarro, G., Varani, K., Reyes-Resina, I., Sánchez de Medina, V., Rivas-Santisteban, R., Sánchez-Carnerero Callado, C., ... & Franco, R. (2018). Cannabigerol action at cannabinoid CB1 and CB2 receptors and at CB1–CB2 heteroreceptor complexes. Frontiers in pharmacology, 9, 632.
    2. Anderson, B. D., Sepulveda, D. E., Nachnani, R., Cortez-Resendiz, A., Coates, M. D., Beckett, A., ... & Raup-Konsavage, W. M. (2024). High cannabigerol hemp extract moderates colitis and modulates the microbiome in an inflammatory bowel disease model. Journal of Pharmacology and Experimental Therapeutics, 390(3), 331-341.
    3. Benjamin D. Anderson, Diana E Sepulveda, Rahul Nachnani, Alonso Cortez-Resendiz, Matthew D. Coates, Aviauna Beckett, Jordan E Bisanz, Joshua J Kellogg and Wesley M Raup-Konsavage
    portrait of Ana
    BY
    Anna Deutschman

    Masters Degree in English Literature, Educator & Content Writer Anna Deutschman is an educator and content writer with a Master's degree in English Literature. Throughout her career, Anna has dedicated herself to both education and writing, refining her skills to produce compelling and inform...


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