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CBD For Arthritis: What The Research Shows

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According to the Center For Disease Control (CDC), 54 million people in the United States are diagnosed with arthritis—nearly half of whom are limited in their activities because of this condition.

Arthritis is the inflammation of the joints, resulting in stiffness, pain, swelling, and in severe cases, can reduce one's mobility. 

Despite how common arthritis diagnoses are, there is no cure for the condition. Treatments to manage pain have improved over the years, but most of which involve strong pharmaceuticals that come with a higher risk for addiction and undesirable side effects.

Cannabidiol (CBD) is a non-psychotropic compound from the cannabis plant that has been extensively studied for its benefits towards supporting a healthy inflammatory response and pain relief while having a very low risk for side effects and addictions.

In this article, we'll look at what current research says about the potential of CBD oil for arthritis and how other people are using CBD at home to manage their symptoms.


  1. Arthritis is a disease described as the inflammation of the joints and it affects roughly 54 million people in the United States
  2. There is no cure for arthritis, only methods to ease the comfort of those living with arthritis or therapies that can improve the success rate of remission
  3. CBD has gentle and broad-acting benefits such as supporting a normal inflammatory response and increasing comfort that may help improve the quality of life of those living with arthritis
  4. CBD is a versatile compound that can be used effectively internally and topically—but there is no CBD product available that has been approved by the Food and Drug Administration (FDA) to treat arthritis or any auto-immune condition
  5. Not all CBD products offer the same level of benefits—it's important to shop for quality CBD that has been lab-tested to ensure its safety
  6. Don't take CBD without first speaking with your doctor if you have arthritis or are on any form of medication 

Does CBD Oil Help Arthritis?

There is currently no cure for arthritis, but quality nonprescription CBD products may provide gentle and noticeable pain relief to improve the quality of people's lives.

While research on CBD and other cannabis plant compounds on arthritis symptoms is relatively new, there's a lot of evidence (through relevant animal studies) to suggest that CBD reduces inflammation, which can help provide pain relief for people with arthritis with very few mild side effects.

Since pain and swelling, which are mechanisms of the immune system, are involved with inflammation, CBD products applied topically or taken internally may help to reduce discomfort associated with inflammatory pain. Specifically, CBD has been shown to modulate the production of cytokines, which are proteins that play a role in the inflammatory response [1].

Studies have also shown that higher doses of CBD may offer some support for arthritis pain by interacting with the vanilloid pain receptors, specifically the TR1PV receptor [3]. This receptor sends pain signals to the brain when something is hot to touch or in pain.

When it comes to joint pain and arthritis, inflammation triggers the sensation of pain. Utilizing CBD gummies for joint pain may potentially block this signaling pathway, thereby reducing the sensations of pain. However, more research is needed to confirm these effects.

What Causes Arthritis Pain?

What Causes Arthritis Pain?

The main symptoms of arthritis are the swelling and pain experienced in one or more joints that typically get worse as you get older. 

The most common forms of arthritis are osteoarthritis, rheumatoid arthritis, and gout.


Osteoarthritis is nicknamed the "wear-and-tear" disease. 

It develops slowly and worsens with age. While it can affect any joint, the most common joints affected by osteoarthritis are the spine, hips, hands, and knees.

In osteoarthritis, the cartilage that cushions the connection between the bones and joints gradually degrade and the bone ends up rubbing on another bone. This disease can also affect the entire joint—the bone, and connective tissue—causing chronic pain, stiffness, and disability.

Factors that increase the risk of osteoarthritis include genetics, old age, women, joint injuries, obesity, poor bone density, and diabetes.

Rheumatoid Arthritis

Rheumatoid arthritis (RA) is classified as an autoimmune and inflammatory disease. It happens when a dysfunctional immune system attacks healthy cells in the joints causing an inflammatory response that leads to painful swelling around the area. The swelling and pain can be so drastic that it begins to wear away at the joint itself leading to deformity and disability.

RA mainly manifests itself as joint pain. However, as an inflammatory disease, it can cause a lot of damage to other systems as well such as the skin, kidneys, and circulatory system.

While rheumatoid arthritis can affect anyone, it's most prevalent in women between the ages of 30–60 [1]. Family history, smoking, obesity, and age can put you at higher risk for developing rheumatoid arthritis.


Gout is a form of arthritis that occurs when uric acid builds up in the blood and forms into crystals in the joints causing inflammation and intense pain or a "gout attack."

The joints affected are typically the toes, ankles, knees, wrists, elbows, and hands that come on suddenly and can last up to 12 hours of intense pain that may subside into lingering pain for several weeks.

In healthy individuals, the kidneys can eliminate excess uric acid through urination. However, genetics, obesity, certain diets, excessive alcohol use, and injury can make some people more susceptible to gout attacks.

How People Are Using CBD For Arthritis

How People Are Using CBD For Arthritis

The only prescription CBD product approved by the Food and Drug Administration is Epilodex, and its use as a treatment for epilepsy. More research is needed in the space for CBD for arthritis—but that hasn't stopped people from using CBD products to support their wellness goals.

We'll go over some of the ways experts and experienced CBD users alike are finding success in using CBD to support chronic pain as a result of their arthritis condition. However, if you've been diagnosed with an underlying condition or are on any medications, it's advised that you speak with your doctor before experimenting with the potential benefits of CBD on your own

1. Shop For High-Quality CBD Products

There are a lot of snake oil CBD products out there that may do you more harm than good, so it's important to know what to look out for when shopping for CBD oil.

First off, make sure you're shopping for hemp-derived CBD that contains no more than 0.3% THC. Any more than this and you could find yourself in legal hot water—depending on your state. And find yourself feeling the intoxicating effects of THC.

Reputable brands will opt for third-party lab testing to demonstrate the THC and CBD content along with a contamination report to show you that the extract is free from harmful chemicals, pesticides, and mold.

2. Leverage The Entourage Effect From Your CBD Product

The entourage effect is a phenomenon in plant medicine that describes the natural compounds of a botanical working in synergy to produce more potent and well-balanced effects. CBD is one of the hundreds of naturally occurring compounds in hemp. Cannabinoids like CBN, CBG, CBC, and even trace amounts of THC can help to amplify the effects of CBD in the body.

The only extract types that can leverage the entourage effect are full spectrum and broad spectrum extracts. Full spectrum extracts closely resemble the phytochemical makeup of the hemp plant, they may cost more as the extraction process has to be much more careful to preserve heat and light-sensitive terpenes and cannabinoids, but experts consider full spectrum the best extract type for potency and effect profile.

For those looking for a CBD product without any THC, broad spectrum extracts are the next best bet. These undergo another process to isolate and remove all traces of THC, while still maintaining a lot of beneficial plant compounds to produce stronger effects.

While CBD isolate products are generally cheaper, you may find that you need more of the product to achieve the same levels of effects compared to full spectrum and broad spectrum extracts.

3. Use Moderate To Higher Doses Of CBD

Everyone's dose requirements for CBD will be different, so you can expect to experiment with your CBD doses until you find the effects you're looking for.

Most studies have found that moderate to higher doses of a quality CBD oil to be more effective in supporting inflammation and pain. Our CBD Rub, formulated with a potent 2000mg of CBD up to 16000mg offers an additional avenue for targeted relief.

If you're new to CBD, it's recommended to start on the lower side of dosing and increase the amounts gradually, to reduce the risk of taking too much and having a negative experience.

4. Supplement CBD Products Consistently

Most people won't find the effects they're looking for from CBD in the first day or even week of use. This is because CBD has broad-acting effects on the endocannabinoid system, and it may take some time for your body to become accustomed to CBD supplementation.

It's important that you take your CBD oil regularly to give it enough time to start producing the results—for some people, it can take several weeks.

5. Use CBD Topically And Internally

Use CBD Topically And Internally
Neurogan Full Spectrum CBD Roll 4000MG in 2oz white bottle

CBD Roll On

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Our CBD Roll On swiftly alleviates muscle soreness, delivering immediate pain relief coupled with a refreshing cooling effect to soothe your body. In this 4000MG powerhouse, CBD interacts synergistically to...

Endocannabinoid receptors are found throughout the body, including skin tissues to support homeostasis, making CBD an incredibly diverse ingredient.

Many people find that applying topical CBD to targets of arthritis pain alongside internal supplementation of CBD helped to ease their discomfort.

When shopping for a topical CBD product to support arthritis pain and inflammation, make sure it has a high concentration of CBD—and that is backed with lab tests to prove it. A lot of products out there claim to contain CBD to support pain, but in reality, don't have enough CBD to have any effects.

Heating and cooling rubs are best for supporting pain. Just make sure to patch test the topical CBD products on a small area of skin before applying it to a tender area to ensure you don't have any negative reactions to the ingredients.

6. Use CBD Alongside Other Joint Supportive Supplements And Exercise

While research is promising surrounding the potential health benefits of CBD, it's not a cure-all compound.

Most people with arthritis find the most success with CBD when they combine its use alongside other forms of supplementation, regular exercise, and therapies such as massage and acupuncture to improve mobility and manage pain.

Best 5 CBD Products For Arthritis 

CBD oil is becoming increasingly popular as a natural remedy for various health conditions, and many people wonder if it can help relieve arthritis pain.

While more solid scientific evidence is needed to support the use of CBD oil for arthritis, many people still turn to CBD products from Neurogan for pain control.

Here we will take a look at six of the best CBD products for arthritis and discuss how they may help provide relief from symptoms.

1. CBD Freeze Roll On

Neurogan freeze roll on

The CBD Freeze Roll-On is one of our best-selling products for fast-acting muscle and joint support. It contains 4000 MG of CBD in a 2-oz container featuring a ball roller applicator that allows you to glide on the formula with a gentle massage, mess-free.

Our customers have dubbed this the best CBD product for arthritis because it delivers the benefit of CBD to the skin almost instantaneously and provides targeted relief to sore joints and muscles with a gentle cooling sensation.


  • Potent full spectrum CBD for the entourage effect

  • Fast-acting and targetted comfort

  • Roll-on applicator makes it easy to massage into the skin, mess-free

  • Cooling menthol botanical formula provides additional comfort for pain management


  • Some people may be sensitive to the menthol and peppermint essential oils

2. CBD Balm Full Spectrum CBD

Neurogan CBD balm 8000 mg

Neurogan Full Spectrum CBD Roll 4000MG in 2oz white bottle

CBD Roll On

Learn More
Our CBD Roll On swiftly alleviates muscle soreness, delivering immediate pain relief coupled with a refreshing cooling effect to soothe your body. In this 4000MG powerhouse, CBD interacts synergistically to...

Due to skin sensitivities, the high-potency CBD Balm is an excellent option for those who prefer something that doesn't leave a cooling sensation on the skin.

This product has a richer yet non-greasy formula from botanical ingredients and beeswax that lasts longer for joint pain relief and irritated skin.

The balmy texture is easy to massage onto tight or sore areas and helps to moisturize and protect the skin while it soaks in to work its magic.


  • Light lavender scent

  • 4000-8000 MG of full spectrum CBD

  • Fast-acting and long-lasting


  • Includes beeswax, so it might not be suitable for plant-based lifestyles

3.CBD + ACV Vegan Gummies

Hand holding strawberry and apple cider + CBD inflammation fighter gummies.

Neurogan Full Spectrum CBD Oil 12000MG citrus, 2oz brown glass bottle, white rubber dropper top

High Potency CBD Oil 12000MG

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CBD Oil 12000MG (2oz) is the champion strength tincture that dreams are made from. This is the highest potency CBD on the market and is derived from award-winning hemp that’s...

When formulating effective CBD products for arthritis, it's essential to look at the root cause of arthritis: inflammation.

Early research suggests that CBD has anti-inflammatory properties by supplementing the endocannabinoid system, which supports the healthy function of the immune system.

Additionally, medical marijuana and hemp research suggests that cannabinoids directly interact with inflammatory enzymes responsible for signaling swelling and pain. By inhibiting these enzymes, CBD and other cannabinoids can potentially treat joint pain [1].

CBD makes for a powerful combination with apple cider vinegar, as it's high in acetic acid, touted for its inflammation-fighting properties [2].

Best of all, our CBD + ACV gummies come in a tasty gummy formula that helps to make getting your daily dose of CBD and acetic acid easy. For many people, especially seniors dealing with joint discomfort, CBD has proven to be a valuable support for maintaining mobility and comfort in old age, especially when you purchase CBD gummies for seniors


  • Plant-based gummy formula, hand-poured in our San Diego, California facility

  • 25 MG of full spectrum CBD with ACV, vitamin B, and folic acid

  • Pre-dosed CBD makes administration easy


  • Only available in one potency 1000 MG CBD per bottle

4. High Potency CBD Oil 12000 MG

Neurogan 12000 mg cbd oil

We're proud to produce the strongest full spectrum CBD oil on the market to support various wellness goals. Many of our customers use our high potency 12000 MG CBD oil to find comfort from arthritis pain and nerve damage symptoms.

Since everyone's needs for CBD oil can vary from person to person and symptom to symptom, having a high-potency CBD oil on your hands can come in handy as it allows you to adjust the dosage drop by drop, depending on the level of discomfort that day.


  • Available in broad spectrum and full spectrum CBD oil

  • Available in three flavors: Citrus, Cinnamon, and Natural Hemp

  • Fast-absorbing MCT oil

  • Allows you to scale your dosage

  • The most cost-effective CBD product


  • The natural terpenes in whole hemp extracts may leave a bitter aftertaste

5. CBD Cigarettes (No Nicotine, Nonpsychoactive)

Hand holding Neurogan CBD cigarettes in a field

Those with more widespread chronic pain often prefer to smoke or vape CBD flower for relief as it quickly enters the bloodstream. The Neurogan CBD cigarettes are made from federally compliant hemp crops with high CBD content and machine-rolled into a neat cigarette shape with a robust filter.

One of the benefits of CBD, when smoked, is that a higher concentration of the active cannabinoids and terpenes interact with the endocannabinoid system, making this the most potent form of CBD administration—though it's not for everyone.


  • High potency full spectrum hemp crops sun grown

  • Robust paper filter and neat-cigarette shape

  • No nicotine, nonpsychoactive

  • Fast-acting


  • It doesn't last as long (1-3 hours)

  • Difficult to measure the dose

Safety And Side Effects of CBD Products for Arthritis

CBD is considered safe, and with physical therapy, lifestyle changes, and guidance from a healthcare professional, using CBD for arthritis pain may be worth trying to support a better quality of life.

The biggest concern for CBD products on the market is the lack of regulation and quality control, which is why there are so many ineffective and potentially dangerous products on the market.

The best CBD products for arthritis should meet the following criteria:

  • It should come from organic hemp (Cannabis Sativa) plant grown in the United States.

  • High CBD content, especially in topical formulas, interacts with cannabinoid receptors in the skin to provide relief.

  • Third-party lab tests to verify the CBD product contents and safety profile

  • Come from a trusted CBD brand with a strong track record for customer satisfaction.

The Takeaway: Does CBD Oil Help Arthritis?

The benefits of CBD for arthritis are discussed everywhere these days. And while more clinical data from human trials are needed to confirm these findings, there are plenty of relevant animal studies and anecdotal reports of people using CBD oil to help arthritis with great success.

If you're planning to use CBD products for arthritis, it's essential to do your research. It's important to understand that even the best CBD products aren't meant to substitute for advice from your healthcare professional and other medications.

To address the growing curiosity of people looking to use CBD products for arthritis, the Arthritis Foundation set out a helpful guide that might be worth looking into.

Neurogan is proud to produce a wide range of CBD products that are safe, affordable, and effective for supporting a healthy lifestyle. If you have any questions or concerns about our CBD, feel free to reach out to our team—we'd be happy to help you navigate this space.


Can CBD Help With Arthritis?

CBD provides gentle and broad-acting advantages, such as promoting a normal inflammatory response and enhancing comfort, which may assist patients suffering from arthritis improve their quality of life. Although CBD is a flexible molecule that may be used both internally and topically, no CBD product has been approved by the Food and Drug Administration (FDA) to treat arthritis or any other auto-immune condition. 

How To Use CBD For Arthritis?

Shopping for high-quality CBD products, leveraging the entourage effect from CBD products, taking moderate to higher doses of CBD products, using CBD consistently, using topical CBD products and other joint support supplements, and exercising while taking CBD products are some of the ways experts and experienced CBD users alike are finding success in using CBD to support chronic pain as a result of their arthritis condition. However, if you have an underlying ailment or are on any drugs, you should consult your doctor before experimenting with the possible advantages of CBD on your own.

What Are The Potential Side Effects Of CBD?

One reason individuals with arthritis are turning to CBD products is that it's a safe substance with few adverse effects—but that doesn't imply it's completely risk-free. CBD may cause the following negative effects: dry mouth, dizziness, nausea, upset stomach, and weariness.

Is It Safe To Use CBD With Other Pain Killers?

CBD seldom interacts with prescription pharmaceuticals, and it's generally safe to take with over-the-counter pain relievers like Tylenol and Ibuprofen, but some drug therapies for arthritis pain are highly strong and are meant to impact immune system function. It's best to consult your doctor before using CBD in conjunction with arthritic medicines.


  1. Angum, F., Khan, T., Kaler, J., Siddiqui, L., & Hussain, A. (2020). The prevalence of autoimmune disorders in women: a narrative review. Cureus, 12(5).
  2. Nichols, J. M., & Kaplan, B. L. (2020). Immune responses regulated by cannabidiol. Cannabis and cannabinoid research, 5(1), 12-31.
  3. Russo, E. B. (2008). Cannabinoids in the management of difficult to treat pain. Therapeutics and clinical risk management, 4(1), 245.
  4. Ruhaak, L. R., Felth, J., Karlsson, P. C., Rafter, J. J., Verpoorte, R., & Bohlin, L. (2011). Evaluation of the cyclooxygenase inhibiting effects of six major cannabinoids isolated from Cannabis sativa. Biological and Pharmaceutical Bulletin, 34(5), 774-778.
  5. Costa, B., Giagnoni, G., Franke, C., Trovato, A. E., & Colleoni, M. (2004). Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation. British journal of pharmacology, 143(2), 247-250.
  6. Pretzsch, C. M., Freyberg, J., Voinescu, B., Lythgoe, D., Horder, J., Mendez, M. A., ... & McAlonan, G. M. (2019). Effects of cannabidiol on brain excitation and inhibition systems; a randomised placebo-controlled single dose trial during magnetic resonance spectroscopy in adults with and without autism spectrum disorder. Neuropsychopharmacology, 44(8), 1398-1405.
Katrina Lubiano

BA in English Katrina has always had a passion for health sciences and literature. She works as a content writer, editor, and strategist in the health and wellness space, primarily focusing on cannabis education. She’s written well over 400,000 words on the subject—including demystifying laws a...

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