Cannabichromene, or CBC, and cannabigerol, or CBG, are compounds derived from the hemp plant. Although they come from the same plant, they interact with the bodies differently and have distinct properties. Their different properties and effects mean that one may better fit into your wellness plan than the other.
CBC vs CBN: Main Differences
The main difference between CBC and CBN is that CBC is a non-psychoactive compound primarily known for its anti-inflammatory potential. CBN is derived from degraded THC and has mild psychoactive effects, and is commonly associated with sleep support.
Plant Differences
CBC and CBN come from the same plant, but their concentrations vary depending on the age of the cannabis plant.
- CBC Benefits
- Supports Antimicrobial Defense
- According to early research, CBC has demonstrated potential in supporting the body’s natural defenses against certain microbes, including resistant strains like MRSA [1].
- Neuroprotective Support
- Some studies suggest that CBC may help promote brain health by supporting the growth of new neurons (a process known as neurogenesis), which could contribute to overall cognitive function [2]. Similarly, CBG is also recognized for its potential focus-enhancing properties, making both CBC and CBG appealing choices for those interested in cognitive support
- Mood Support
- Preliminary research indicates that CBC may support a positive mood by interacting with the endocannabinoid system, which contributes to regulating emotions and stress responses [3].
- CBN Benefits
- Promotes Relaxation and Calm
- CBN is often associated with promoting a sense of relaxation, which may be helpful for individuals seeking support for restful sleep when combined with other cannabinoids and terpenes [4].
- Supports Healthy Appetite
- CBN has been shown to potentially stimulate appetite without producing the psychoactive effects that are associated with THC [5].
- Supports Antibacterial Defense
- CBN has exhibited potential antibacterial properties in preclinical studies, suggesting it may help support the body’s ability to fight certain bacterial infections, but the FDA has not approved it for this use [5].
The following potential benefits of CBC and CBN are based on early research. You shouldn’t use these cannabinoids to self-treat, cure, or manage any health condition. While promising, more studies are needed to understand CBN and CBC’s effects in humans.
Similarities of CBC and CBN
CBN and CBC are considered minor cannabinoids because they’re found in very small amounts naturally in the cannabis plant, and while they have their own unique traits, they do share some similarities. Both may support relaxation and the body’s overall wellness through interactions with the ECS.
- Supports Healthy Inflammatory Responses
- CBC has shown potential in supporting a healthy inflammatory response without engaging cannabinoid receptors that produce psychoactive effects. [1].
- CBC interacts with CB1R, CB2E, TRPA1, and adenosine receptors. This interaction is thought to help lower inflammation by reducing the activity of immune cells called macrophages that are involved in the body’s inflammatory response [1].
- Potential for Comfort and Relief
- Studies on animal models indicate that both CBC and CBN may potentially support the body’s natural response to discomfort. Users often report incorporating these cannabinoids into their wellness routines for their soothing properties, although human studies are still ongoing [7].
- Calming Effects
- CBN is commonly associated with promoting relaxation, making it popular for those seeking to unwind. CBC may also have calming properties, although its specific role in promoting relaxation is still being explored in research settings.
CBC vs CBN: Which Should You Choose?
As you can see, CBC and CBN share similar benefits but also offer unique ones.
Before implementing a cannabinoid into your wellness routine, it’s best to be informed about the potential effects and benefits. While you can compare cannabinoids to each other on your own and decide which one aligns best with your health goals, it’s wise to discuss this decision with your healthcare professional.
References:
- Karas, J. A., Wong, L. J., Paulin, O. K., Mazeh, A. C., Hussein, M. H., Li, J., & Velkov, T. (2020). The antimicrobial activity of cannabinoids. Antibiotics, 9(7), 406.
- Gojani, E. G., Wang, B., Li, D. P., Kovalchuk, O., & Kovalchuk, I. (2023). Anti-inflammatory effects of minor cannabinoids CBC, THCV, and CBN in human macrophages. Molecules, 28(18), 6487.
- Shinjyo, N., & Di Marzo, V. (2013). The effect of cannabichromene on adult neural stem/progenitor cells. Neurochemistry international, 63(5), 432-437.
- El-Alfy, A. T., Ivey, K., Robinson, K., Ahmed, S., Radwan, M., Slade, D., ... & Ross, S. (2010). Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L. Pharmacology Biochemistry and Behavior, 95(4), 434-442.
- Brierley, D. I., Samuels, J., Duncan, M., Whalley, B. J., & Williams, C. M. (2016). Cannabigerol is a novel, well-tolerated appetite stimulant in pre-satiated rats. Psychopharmacology, 233, 3603-3613.
- Caupain, A., & Hupli, A. (2023). Potential Antibacterial Application of Cannabinoids: A Narrative Review of Preclinical Studies. The American Journal of Endocannabinoid Medicine, 4(2).
- Raup-Konsavage, W. M., Sepulveda, D. E., Wang, J., Dokholyan, N. V., Vrana, K. E., & Graziane, N. M. (2023). Antinociceptive Effects of Cannabichromene (CBC) in Mice: Insights from von Frey, Tail-Flick, Formalin, and Acetone Tests. Biomedicines, 12(1), 83.
