Cannabigerolic acid, or CBGa, is a minor cannabinoid found naturally in young, flowering cannabis plants—and it's nicknamed the "mother cannabinoid" as it's the precursor to the two main cannabinoids, CBDa (cannabidiolic acid) and THCa (tetrahydrocannabinolic acid) that eventually turn into CBD and THC through a process called decarboxylation.
CBGa and any other cannabinoid with the "a" affixed to it is the natural form of the compound that still contains a carboxylic acid group to the molecule.
Exposure to heat or UV breaks off the carboxylic acid chain, represented with the letter "a" leaving behind CBG. This slight variation in molecule structure may have unique effects in terms of pharmacology.
The research into cannabis's chemical compounds are primarily focused on THC and CBD, but early animal and human trials suggest that CBGa may effectively target unique pathways that may support viral infection, heart health, and metabolic disorders.
Cannabigerolic Acid Overview
The cannabis Sativa plant is a member of the Cannabaceae family, which includes several other plants such as hops and hackberry.
The cannabis plant is the oldest medicinal plant used by humans and is rich in cannabinoids that inter with the endocannabinoid system [1]. The most well-known cannabinoids are tetrahydrocannabinol (THC) and cannabidiol (CBD).
Before we get THC and CBD—these complex molecules start out in a different form, CBGa or cannabidiolic acid.
Cannabigerolic acid is the precursor to CBDa, THCa. and CBCa (cannabichromene), which starts to express in the resin glands of flowering cannabis plants around 3–4 weeks of the flowering cycle before UV exposure and oxidation transforms the molecule into its other forms.
By the time the cannabis plant matures (7-8 week period), there's very little CBGa that remains as it has converted into other acidic cannabinoids, which is why it's considered a minor cannabinoid.
However, with more cannabis breeders finding new ways to selectively breed strains that contain higher levels of CBGa, and more precise extracting processes a lot more attention is being placed on minor cannabis compounds for their potential wellness benefits.
How Do You Get CBG From CBGa?
If you've ever planned to buy CBD oil, chances are you've come across the terms CBDa, CBG, CBGa, and other cannabinoids with carboxylic acid groups.
But what do they all mean? In short, CBDa and CBGa are acidic cannabinoids that occur naturally in cannabis plants.
The "a" at the end of CBGa stands for "acid."
These acids are called carboxylic acids because they contain a carboxyl group (COOH)—a carbon atom bonded to an oxygen atom and a hydrogen atom.
When heated, these acids undergo a process called decarboxylation, which removes the carboxyl group and changes the molecule's chemical structure.
As a result, CBGa is converted into CBG—THCa into THC—and CBDa into CBD.
So, when you see a product containing CBG, it means that the plant material has been heated to remove the carboxyl group and produce CBG.
It was once believed that decarboxylation was necessary to harness the full potential therapeutic benefits of cannabinoids—but that may not be true.
Raw hemp extracts and raw cannabinoids such as cannabidiolic acid (CBDa) gained new popularity, with more research programs investing in these compounds' potential unique benefits in the endocannabinoid system.
These early studies show that cannabinoids don't necessarily have to be in their decarboxylated form to be biologically active. Consuming them in their most natural state may be some health benefits worth studying.
What Are The Benefits Of CBGa?
We’re still waiting on more medical research to understand better the benefits CBGa may offer.
While some potential effects and benefits of CBG overlap with more well-researched cannabinoids like THC and CBD, CBGa offers distinct effects as well. Current CBGa research suggests that It may have anti-cancer properties, help the immune system, and support heart health among others.
Please keep in mind that we’re looking at what the research says about CBGa for educational purposes only, and we are not implying that CBGa products should be used in replacement for any treatment provided by a healthcare professional as it’s not an FDA-approved compound.
CBGa Benefits:
- Anti-Cancer Research
- Heart Health
- Brain Health
Anti-Cancer Research
While we need research conducted on human bodies to know the effects on humans, research on murine models has shown that CBGa can inhibit the growth of cancerous tumors [1].
By regulating cell proliferation and cell death, its been found to interrupt the cancer cell cycle. Murine models can be really exciting because they highlight the potential for positive effects in human bodies. This kind of research encourages more research on the clinical level.
Heart Health
A healthy heart is a pillar of our overall health, so preventative care for our heart is one of the best things we can do to support our health. Keeping your blood pressure at desirable levels is one of the best ways to support heart health.
In some animal trials, CBGa demonstrated an ability to support lowering blood pressure and slow the progression of atherosclerosis [2].
Anti-inflammatory Properties
A study published in 2023 examined the anti-inflammatory effect of CBGa in an in vitro LPS-induced model of inflammation [3]. This study demonstrated a reduction in pro-inflammatory cytokines tested [3]. The researchers of this study encourage further studies on CBGa’s potential effect on inflammatory skin conditions.
Cannabinoids and their potential anti-inflammatory effects have long been of interest to researchers and the medical community. Hopefully, as more research is conducted, we will start to understand the full scope of CBGa's potential uses for anti-inflammatory purposes.
CBGA vs CBG: Form, Function & Availability
Form: CBGa is the acid form and the precursor to other cannabinoids such as CBG, CBD, and THC. The transformation from CBGa into these other cannabinoids happens through a process known as decarboxylation, typically involving heat, where CBGa loses a carboxyl group.
Function: CBGa, often referred to as the "stem cell" of the cannabis plant, plays a pivotal role in the production of other cannabinoids. On the other hand, CBG, which is one of the final forms of cannabinoids, might have potential health benefits, including reducing inflammation, pain, and nausea.
Availability: The presence of these cannabinoids in the cannabis plant varies. CBG is usually present in low concentrations in most strains, as most CBGa is converted into other cannabinoids. However, some breeders have managed to cultivate strains with higher levels of CBG. In contrast, CBGa is generally found in abundance in young cannabis plants before its conversion into other cannabinoids.
How Do You Take CBGa Oil Or Capsules For The Best Results?
Compared to CBDa, CBD, and CBN, CBGa research is still in its early stages, and there aren't very many CBGa-specific products available yet—but we're sure you'll find them hitting the market very soon.
You can take CBGa the same way you would take your CBD products.
Remember cannabinoids affect individuals differently—what works for one individual isn't necessarily what's going to be best for you. Factors can depend on your genetics, experience with cannabinoids, and your wellness goals.
Since cannabinoids are fat-soluable compounds, it's best to take your CBGa products with a light meal to increase its absorption through the digestive system, similar to CBD.
It's also recommended that you consume cannabinoids regularly—they're not miricle-cure compounds—rather they supplement the body's chemical messengers involved in maintaining homseostasis, which can potentially support one's overall wellbeing. As such, it's best to take these types of products consistently as a long-term regimen.
Another thing to be aware of when using CBGa or any other raw hemp compounds is that they tend to have a shorter shelf life as they're much more susceptible to heat, UV, and oxidation. This means, you should look to purchase fresh CBGa products to keep the CBGa content high before the chemical compounds eventually transform onto other cannabinoids or degrade.
Taking expired cannabinoids isn't necessarily dangerous, but it can reduce the potency and effectiveness of the product.
What Are The Potential Risks Of CBGa?
CBGa is still fairly new, and not well understood in human trials, there's not much safety information about the cannabinoid. However, many cannabinoids like CBDa, CBD, and even THC—which has psychoactive effects—have been found to be non-toxic and well-tolerated.
Some of the side effects of consuming too many CBG cannabinoids are:
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Nausea
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Stomach upset
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Headaches
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Drowsiness
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Lethargy
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Appetite changes
That being said, the biggest concern for safety when it comes to any cannabinoid product is the manufacturing. The hemp plant is sensitive to its growing environment, which means it soaks up the good and the bad.
Overview on Cannabigerolic Acid
CBGa or cannabigerolic acid is a naturally occurring compound found in the trichomes of cannabis plants. It's sometimes called the "mother cannabinoid" because this molecule eventually transforms into CBDa, THCa, and other cannabinoids.
Decarboxylation is a process that removes the carboxylic acid chain from the molecule, transforming CBGa into CBG. It was one believed that heat was needed to "activate" these cannabinoids for increased bioavailability. But now researchers are investigating the potential benefits of cannabinoid acids.
Some early studies suggests that CBGa may be useful for supporting a variety of conditions including, inflammation, viral infection, cancer growth, and cardiovascular disease—However, most of these studies are in their very early stages and more investigation is needed to fully understand the potential and safety of this compound.
FAQ
What is CBGa?
Cannabigerolic acid, or CBGa, is a minor cannabinoid found naturally in young, flowering cannabis plants—and it's nicknamed the “mother cannabinoid” as it's the precursor to the two main cannabinoids, CBDa (cannabidiolic acid) and THCa (tetrahydrocannabinolic acid) that eventually turn into CBD and THC through a process called decarboxylation.
What are the benefits of CBGa?
There's very little medical research available on CBG, let alone cannabigerolic acid. Much of the cannabis research is focused heavily on two cannabinoids: CBD and THC, but there's still a collection of promising studies centered around this foundational compound. Some researched benefits are CBGa may block viral entry of SARS-CoV2, and may support heart health and metabolic disorders. Some studies have also shown that CBGa may have anti-cancer properties and potent anti-inflammatory properties.
How to get CBG from CBGa?
Exposure to heat or UV breaks off the carboxylic acid chain, represented with the letter “a” leaving behind CBG. This slight variation in molecule structure may have unique effects in terms of pharmacology.
What are the potential risks of CBGa?
Too much cannabis can have a number of side effects, including nausea, upset stomach, headaches, tiredness, lethargy, and changes in appetite. In light of this, production is the main source of safety concern for any cannabinoid product. Because it is sensitive to its growing conditions, the hemp plant takes in both the good and the negative. Additionally, there are numerous potentially hazardous extraction techniques that could leave irritant compounds in the finished product. To avoid any problems, thoroughly investigate cannabis goods before buying. Before you buy CBGa online or in stores, look for recognized third-party lab tests that can confirm the cannabis concentration and contaminant report.
Do CBGa gummies make you sleepy?
CBGa gummies may cause drowsiness as a potential side effect. While further research is needed to establish a definitive link between CBGa and sleepiness, anecdotal reports suggest that some individuals may experience drowsiness after consuming CBGa gummies. It is important to note that individual responses may vary, and other factors such as dosage and personal tolerance can also influence the effects.
What is the use of CBGa flower?
CBGa serves as a precursor to major cannabinoids like THC and CBD, making it valuable for research and product development in the cannabis industry. Its therapeutic potential, including anti-inflammatory, analgesic, and neuroprotective properties.
What does CBGa oil good for?
CBGa oil, derived from cannabigerolic acid (CBGa), offers potential therapeutic benefits due to its interaction with the endocannabinoid system. As a precursor to other cannabinoids like CBD and THC, CBGa oil may possess anti-inflammatory and analgesic properties, making it a potential candidate for managing pain and inflammation.
Resources:
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Farag, S., & Kayser, O. (2017). The cannabis plant: botanical aspects. In Handbook of cannabis and related pathologies (pp. 3-12). Academic Press.
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van Breemen, R. B., Muchiri, R. N., Bates, T. A., Weinstein, J. B., Leier, H. C., Farley, S., & Tafesse, F. G. (2022). Cannabinoids block cellular entry of SARS-CoV-2 and the emerging variants. Journal of natural products, 85(1), 176-184.
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Smeriglio, A., Giofrè, S. V., Galati, E. M., Monforte, M. T., Cicero, N., D'Angelo, V., ... & Circosta, C. (2018). Inhibition of aldose reductase activity by Cannabis sativa chemotypes extracts with high content of cannabidiol or cannabigerol. Fitoterapia, 127, 101-108.
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D'Aniello, E., Fellous, T., Iannotti, F. A., Gentile, A., Allarà, M., Balestrieri, F., ... & Di Marzo, V. (2019). Identification and characterization of phytocannabinoids as novel dual PPARα/γ agonists by a computational and in vitro experimental approach. Biochimica et Biophysica Acta (BBA)-General Subjects, 1863(3), 586-597.
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Nallathambi, R., Mazuz, M., Namdar, D., Shik, M., Namintzer, D., Vinayaka, A. C., ... & Koltai, H. (2018). Identification of synergistic interaction between cannabis-derived compounds for cytotoxic activity in colorectal cancer cell lines and colon polyps that induces apoptosis-related cell death and distinct gene expression. Cannabis and cannabinoid research, 3(1), 120-135.
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Nallathambi, R., Mazuz, M., Ion, A., Selvaraj, G., Weininger, S., Fridlender, M., ... & Koltai, H. (2017). Anti-inflammatory activity in colon models is derived from δ9-tetrahydrocannabinolic acid that interacts with additional compounds in cannabis extracts. Cannabis and
